HPS1

Across TCGA patient cohorts, HPS1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HPS1-associated genes across cancer lineages are BRCA2, Fibronectin, and JNK2. Each is linked with HPS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HPS1-to-partner and partner-to-HPS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BRCA2 grouped by HPS1-low versus HPS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPS1→partner) and Y-score (partner→HPS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BRCA2 →	-0.097	-1.407	.042	.046	3	2
UCEC	Fibronectin →	-0.308	-2.247	.010	.001	3	1
UCEC	JNK2 →	+0.251	+1.847	<.001	.008	3	1
UCEC	Ku80 →	+0.268	+2.331	.002	.003	3	1
UCEC	MEK1 →	+0.341	+2.247	.011	.001	3	1
UCEC	Notch1 →	+0.152	+3.335	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

BRCA2 by HPS1 expression — UCEC

Explore this box plot interactively →