HPRT1

Across TCGA pan-cancer cohorts, HPRT1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HPRT1 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HPRT1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HPRT1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

HNSC, OV, and COAD are the cancer types where HPRT1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.305	0.911	.006	40	view →
OV	DFS	Tertile	All	0.584	1.000	.024	16	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
CCRCC	DFS	Median	All	0.870	0.735	.027	1	view →
LSCC	DFS	Quartile	III,IV	1.000	0.504	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HPRT1–HNSC (DFS)

Open the HNSC breakdown →