HPRT1

Across TCGA patient cohorts, HPRT1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HPRT1-associated genes across cancer lineages are A-Raf_pS299, FOXO3a, and JNK_pT183_Y185. Each is linked with HPRT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HPRT1-to-partner and partner-to-HPRT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by HPRT1-low versus HPRT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPRT1→partner) and Y-score (partner→HPRT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.160	-3.321	.002	.010	3	1
UCEC	FOXO3a →	-0.135	-1.986	.003	.032	3	1
UCEC	JNK_pT183_Y185 →	-0.166	-2.321	.029	.034	3	1
UCEC	JNK2 →	+0.215	+2.834	.016	.034	3	1
UCEC	MEK1 →	+0.511	+3.584	.001	.002	3	1
UCEC	mTOR_pS2448 →	-0.166	-3.150	.013	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

A-Raf_pS299 by HPRT1 expression — UCEC

Explore this box plot interactively →