HPGD

Across TCGA pan-cancer cohorts, HPGD mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HPGD data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher HPGD mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated HPGD expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

PDAC, HNSC, and LUAD are the cancer types where HPGD mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	All	0.689	0.385	<.001	57	view →
HNSC	DFS	Tertile	All	1.000	0.215	.014	16	view →
LUAD	DFS	Quartile	III,IV	0.358	0.807	.027	6	view →
CCRCC	OS	Median	III,IV	1.000	0.831	.029	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

HPGD–PDAC (OS)

Open the PDAC breakdown →