HPGD

Across TCGA pan-cancer cohorts, HPGD RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of HPGD’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HPGD RNA is repressed in tumor relative to normal tissue. In most cancer types HPGD is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

HNSC, COAD, and KIRP are the cancer types where HPGD tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HPGD RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	−3.128	<.001	12	view →
COAD	Female	All	−3.524	<.001	11	view →
KIRP	Male	II,III,IV	−2.954	<.001	11	view →
KIRC	Female	All	−2.493	<.001	11	view →
LUSC	Female	II,III,IV	−3.700	<.001	8	view →
LIHC	Male	II,III,IV	−3.123	<.001	8	view →
LUAD	Female	III,IV	−2.637	<.001	7	view →
BLCA	Female	All	−3.631	.004	6	view →
KICH	All	III,IV	−2.795	.003	6	view →
STAD	All	II,III,IV	−2.086	<.001	6	view →
CHOL	Male	All	−4.720	<.001	5	view →
READ	All	All	−3.757	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

HPGD–HNSC

Open the HNSC breakdown →