HPGD

Across TCGA patient cohorts, HPGD protein abundance is significantly associated with the RNA expression of many other genes, with 7,624 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HPGD-associated genes across cancer lineages are U2SURP, HEATR1, and LRPPRC. Each is linked with HPGD in more than 3 cancer types. Because this analysis shows association rather than direction, both HPGD-to-partner and partner-to-HPGD results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HPGD versus U2SURP in HNSC, with a Pearson correlation of -0.26.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPGD→partner) and Y-score (partner→HPGD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	U2SURP →	-0.622	-0.377	.001	.008	3	4
HNSC	HEATR1 →	-0.445	-0.372	.004	.001	3	4
HNSC	LRPPRC →	-0.568	-0.519	<.001	.004	3	4
HNSC	HDC →	+0.966	+0.672	<.001	<.001	3	4
LUAD	COL21A1 →	+1.131	+1.124	<.001	.003	3	4
LUAD	VSIG2 →	+1.733	+1.150	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,624 associations by consensus.

HPGD vs U2SURP — HNSC

Explore this scatter interactively →