HPGD

Across TCGA patient cohorts, HPGD mutation is significantly associated with the RNA expression of many other genes, with 1,998 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HPGD-associated genes across cancer lineages are MIR6851, SALL4P2, and CSPG4P3Y. Each is linked with HPGD in more than 1 cancer types. Because this analysis shows association rather than direction, both HPGD-to-partner and partner-to-HPGD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6851 grouped by HPGD-low versus HPGD-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPGD→partner) and Y-score (partner→HPGD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR6851 →	+0.966	+4.539	<.001	.005	3	2
SKCM	SALL4P2 →	+0.028	+5.436	<.001	.005	3	2
BLCA	CSPG4P3Y →	+0.054	+7.640	<.001	.009	3	2
UCEC	LINC02438 →	+0.591	+2.137	<.001	.001	3	2
UCEC	MIR4672 →	+0.263	+1.626	.005	.007	3	2
LUSC	RBMY1F →	+0.125	+4.724	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,998 associations by consensus.

MIR6851 by HPGD expression — BRCA

Explore this box plot interactively →