Across TCGA patient cohorts, HPDL protein abundance is significantly associated with the RNA expression of many other genes, with 5,047 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible HPDL-associated genes across cancer lineages are NFATC2, SCN1B, and PRLR. Each is linked with HPDL in more than 1 cancer types. Because this analysis shows association rather than direction, both HPDL-to-partner and partner-to-HPDL results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPDL→partner) and Y-score (partner→HPDL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NFATC2 →	-0.820	-1.311	.002	<.001	3	2
BRCA	SCN1B →	-0.870	-1.233	.003	.005	3	2
BRCA	PRLR →	-1.799	-1.185	<.001	<.001	3	2
BRCA	VIPR1 →	-1.368	-1.234	<.001	<.001	3	2
BRCA	ST3GAL5 →	-0.605	-1.006	.006	.006	3	2
BRCA	MAN1C1 →	-1.088	-1.429	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,047 associations by consensus.

Exploration

HPDL survival (RNA) · tumor vs normal (RNA) · all HPDL data types