HPD

Across TCGA patient cohorts, HPD protein abundance is significantly associated with the protein abundance of many other proteins, with 5,956 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible HPD-associated proteins across cancer lineages are ARID2, TAF12, and TRIM28_S138. Each is linked with HPD in more than 2 cancer types. Because this analysis shows association rather than direction, both HPD-to-partner and partner-to-HPD results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HPD versus ARID2 in GBM, with a Pearson correlation of -0.48.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HPD→partner) and Y-score (partner→HPD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ARID2 →	-0.300	-0.750	<.001	<.001	3	2
GBM	TAF12 →	-0.366	-0.683	<.001	.002	3	2
BRCA	TRIM28_S138 →	-0.484	-1.290	.002	.002	3	2
BRCA	UBA6_S36 →	+0.739	+1.526	.002	.002	3	2
BRCA	WDR33_S1210 →	-0.820	-1.748	.002	<.001	3	2
BRCA	WDR82 →	-0.309	-1.451	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,956 associations by consensus.

HPD vs ARID2 — GBM

Explore this scatter interactively →