HPCA

Across TCGA patient cohorts, HPCA RNA expression is significantly associated with the protein abundance of many other proteins, with 14,328 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HPCA-associated proteins across cancer lineages are TNIK_S640, PPP2R2D, and PRDX4. Each is linked with HPCA in more than 2 cancer types. Because this analysis shows association rather than direction, both HPCA-to-partner and partner-to-HPCA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HPCA versus TNIK_S640 in OV, with a Pearson correlation of 0.41.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HPCA→partner) and Y-score (partner→HPCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TNIK_S640 →	+1.193	+0.566	.009	.006	3	3
LUAD	PPP2R2D →	-0.188	-0.292	.004	.005	3	3
GBM	PRDX4 →	-0.370	-1.035	<.001	<.001	3	3
BRCA	STAG2 →	+0.283	+0.631	.001	<.001	3	3
GBM	SEPTIN3 →	+0.820	+2.121	<.001	<.001	3	3
LSCC	DNAJC1 →	-0.405	-0.446	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,328 associations by consensus.

HPCA vs TNIK_S640 — OV

Explore this scatter interactively →