HPCA

Across TCGA patient cohorts, HPCA protein abundance is significantly associated with the RNA expression of many other genes, with 5,554 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HPCA-associated genes across cancer lineages are YPEL1, SNRPD3, and PRODH. Each is linked with HPCA in more than 1 cancer types. Because this analysis shows association rather than direction, both HPCA-to-partner and partner-to-HPCA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HPCA versus YPEL1 in GBM, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPCA→partner) and Y-score (partner→HPCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	YPEL1 →	+0.488	+0.803	<.001	<.001	3	1
GBM	SNRPD3 →	+0.501	+1.019	<.001	<.001	3	1
GBM	PRODH →	+0.800	+1.030	<.001	<.001	3	1
GBM	GRK3 →	+0.382	+0.709	<.001	.001	3	1
GBM	SEZ6L →	+1.639	+0.931	<.001	<.001	3	1
GBM	LGALS1 →	-0.677	-1.056	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,554 associations by consensus.

HPCA vs YPEL1 — GBM

Explore this scatter interactively →