HPCA

Across TCGA patient cohorts, HPCA mutation is significantly associated with the RNA expression of many other genes, with 79 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HPCA-associated genes across cancer lineages are MIR6851, RN7SKP230, and RPS3AP30. Each is linked with HPCA in more than 1 cancer types. Because this analysis shows association rather than direction, both HPCA-to-partner and partner-to-HPCA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6851 grouped by HPCA-low versus HPCA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPCA→partner) and Y-score (partner→HPCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6851 →	+0.592	+2.517	.001	.008	3	2
UCEC	RN7SKP230 →	+0.328	+2.967	.009	.003	3	2
UCEC	RPS3AP30 →	+0.097	+3.188	<.001	<.001	3	2
COAD	MTND4P33 →	+0.115	+4.537	<.001	.006	3	2
UCEC	TEX43 →	+0.357	+3.266	<.001	.001	3	1
UCEC	LINC00544 →	+0.114	+2.633	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

MIR6851 by HPCA expression — UCEC

Explore this box plot interactively →