HPCA

Across TCGA patient cohorts, HPCA mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HPCA-associated genes across cancer lineages are p70-S6K, Di-Ras3, and IGFBP2. Each is linked with HPCA in more than 1 cancer types. Because this analysis shows association rather than direction, both HPCA-to-partner and partner-to-HPCA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p70-S6K grouped by HPCA-low versus HPCA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPCA→partner) and Y-score (partner→HPCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p70-S6K →	+0.210	+3.196	.047	.010	3	1
UCEC	Di-Ras3 →	-0.173	-3.169	.034	.020	3	1
UCEC	IGFBP2 →	-1.018	-3.169	.004	.020	2	1
UCEC	Rab11 →	-0.160	-3.169	.044	.020	2	1
UCEC	C-Raf →	+0.235	+3.169	.002	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

p70-S6K by HPCA expression — UCEC

Explore this box plot interactively →