HP1BP3

Across TCGA patient cohorts, HP1BP3 mutation is significantly associated with the RNA expression of many other genes, with 2,203 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HP1BP3-associated genes across cancer lineages are RNA5SP188, SNRPEP7, and NF1P4. Each is linked with HP1BP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both HP1BP3-to-partner and partner-to-HP1BP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP188 grouped by HP1BP3-low versus HP1BP3-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HP1BP3→partner) and Y-score (partner→HP1BP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNA5SP188 →	+0.339	+5.579	<.001	.001	3	3
LUAD	SNRPEP7 →	+0.193	+3.962	<.001	.005	3	2
CESC	NF1P4 →	+0.029	+6.000	<.001	<.001	3	2
CESC	NF1P11 →	+0.123	+5.579	<.001	.001	3	2
HNSC	MBD3L4 →	+0.059	+7.954	<.001	.008	3	2
UCEC	RNU5E-9P →	+0.119	+3.197	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,203 associations by consensus.

RNA5SP188 by HP1BP3 expression — CESC

Explore this box plot interactively →