HOXD9

Across TCGA patient cohorts, HOXD9 protein abundance is significantly associated with the RNA expression of many other genes, with 3,253 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible HOXD9-associated genes across cancer lineages are TOMM22, KNSTRN, and GCNT2. Each is linked with HOXD9 in more than 2 cancer types. Because this analysis shows association rather than direction, both HOXD9-to-partner and partner-to-HOXD9 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HOXD9 versus TOMM22 in LSCC, with a Pearson correlation of -0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD9→partner) and Y-score (partner→HOXD9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TOMM22 →	-0.736	-0.842	<.001	.008	3	3
BRCA	KNSTRN →	-0.961	-0.829	.002	.002	3	3
HNSC	GCNT2 →	-2.051	-0.909	<.001	<.001	3	2
CCRCC	LSM3P2 →	+0.921	+0.889	<.001	<.001	3	2
BRCA	HOXD3 →	+0.903	+0.758	<.001	<.001	3	2
HNSC	ACTR3B →	-0.596	-0.797	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,253 associations by consensus.

HOXD9 vs TOMM22 — LSCC

Explore this scatter interactively →