HOXD9

Across TCGA pan-cancer cohorts, HOXD9 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of HOXD9’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HOXD9 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HOXD9 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

HNSC, KICH, and LIHC are the cancer types where HOXD9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HOXD9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+1.744	<.001	12	view →
KICH	Male	All	−2.626	<.001	10	view →
LIHC	Male	II,III,IV	+1.944	<.001	8	view →
KIRP	All	All	−1.742	<.001	7	view →
UCEC	All	All	−1.710	<.001	6	view →
LUSC	Male	All	+1.440	<.001	6	view →
BRCA	Female	II,III,IV	−1.113	<.001	6	view →
CHOL	All	All	+1.253	.001	4	view →
STAD	All	All	+0.611	<.001	4	view →
ESCA	All	All	+0.903	.011	2	view →
PRAD	All	All	−0.675	<.001	2	view →
COAD	Female	All	+0.777	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

HOXD9–HNSC

Open the HNSC breakdown →