HOXD9

Across TCGA patient cohorts, HOXD9 mutation is significantly associated with the RNA expression of many other genes, with 2,091 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXD9-associated genes across cancer lineages are PGBD4P2, MIR1207, and MIR4698. Each is linked with HOXD9 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXD9-to-partner and partner-to-HOXD9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PGBD4P2 grouped by HOXD9-low versus HOXD9-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD9→partner) and Y-score (partner→HOXD9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	PGBD4P2 →	+0.162	+6.257	<.001	.001	3	2
SKCM	MIR1207 →	+0.525	+5.254	<.001	.001	3	2
UCEC	MIR4698 →	+0.391	+2.653	<.001	.002	3	2
UCEC	MIR5708 →	+0.216	+3.555	<.001	.002	3	2
LUSC	RNVU1-17 →	+0.210	+4.706	.002	.007	3	2
LUSC	MIR4733 →	+0.491	+4.447	.007	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,091 associations by consensus.

PGBD4P2 by HOXD9 expression — READ

Explore this box plot interactively →