HOXD9

Across TCGA patient cohorts, HOXD9 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXD9-associated genes across cancer lineages are MEK1, MSH2, and PDCD4. Each is linked with HOXD9 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXD9-to-partner and partner-to-HOXD9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by HOXD9-low versus HOXD9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD9→partner) and Y-score (partner→HOXD9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.378	+3.459	.021	.005	3	1
UCEC	MSH2 →	-0.231	-2.973	.026	.035	3	1
UCEC	PDCD4 →	-0.648	-2.000	.002	.032	3	1
UCEC	STAT3_pY705 →	-0.308	-2.000	.009	.032	3	1
UCEC	Caspase-8 →	-0.231	-2.973	.041	.035	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.462	-3.000	.022	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MEK1 by HOXD9 expression — UCEC

Explore this box plot interactively →