HOXD9

Across TCGA cell cohorts, HOXD9 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HOXD9-associated genes across cancer lineages are VSIG4, TAFA1, and MINAR2. Each is linked with HOXD9 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXD9-to-partner and partner-to-HOXD9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VSIG4 grouped by HOXD9-low versus HOXD9-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD9→partner) and Y-score (partner→HOXD9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	VSIG4 →	+0.022	+4.285	<.001	.007	3	1
LARGE_INTESTINE	TAFA1 →	+0.209	+2.688	.003	.008	3	1
LARGE_INTESTINE	MINAR2 →	+0.027	+2.882	.003	.005	3	1
LARGE_INTESTINE	C16orf96 →	+0.456	+3.743	.006	.001	3	1
LARGE_INTESTINE	DAZ4 →	+0.123	+3.240	.004	.004	3	1
LARGE_INTESTINE	DAZ2 →	+0.127	+3.678	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

VSIG4 by HOXD9 expression — STOMACH

Explore this box plot interactively →