HOXD8

Across TCGA patient cohorts, HOXD8 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,969 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible HOXD8-associated proteins across cancer lineages are ANGPTL2, PPM1F, and PPP1R12A. Each is linked with HOXD8 in more than 4 cancer types. Because this analysis shows association rather than direction, both HOXD8-to-partner and partner-to-HOXD8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HOXD8 versus ANGPTL2 in CCRCC, with a Pearson correlation of 0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD8→partner) and Y-score (partner→HOXD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ANGPTL2 →	+0.694	+0.601	<.001	<.001	3	5
UCEC	PPM1F →	+0.308	+0.815	<.001	.001	3	4
UCEC	PPP1R12A →	+0.365	+0.915	<.001	<.001	3	4
BRCA	PYGL →	+0.503	+0.878	.001	.005	3	4
BRCA	RRS1 →	-0.509	-1.154	<.001	<.001	3	4
UCEC	TGFB1I1 →	+0.790	+0.960	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,969 associations by consensus.

HOXD8 vs ANGPTL2 — CCRCC

Explore this scatter interactively →