HOXD8

Across TCGA patient cohorts, HOXD8 protein abundance is significantly associated with the protein abundance of many other proteins, with 8,385 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible HOXD8-associated proteins across cancer lineages are SYDE1, TALDO1_S237, and ZC3H18_S34. Each is linked with HOXD8 in more than 2 cancer types. Because this analysis shows association rather than direction, both HOXD8-to-partner and partner-to-HOXD8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HOXD8 versus SYDE1 in UCEC, with a Pearson correlation of 0.46.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD8→partner) and Y-score (partner→HOXD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SYDE1 →	+0.519	+0.780	<.001	<.001	3	3
BRCA	TALDO1_S237 →	+0.941	+0.640	<.001	<.001	3	3
UCEC	ZC3H18_S34 →	-1.102	-1.013	<.001	.002	3	2
OV	MCM2_S139 →	+1.174	+0.644	<.001	<.001	3	2
OV	MCM3 →	+0.907	+0.539	<.001	.005	3	2
OV	MCM4 →	+0.800	+0.543	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,385 associations by consensus.

HOXD8 vs SYDE1 — UCEC

Explore this scatter interactively →