HOXD8

Across TCGA patient cohorts, HOXD8 mutation is significantly associated with the RNA expression of many other genes, with 2,136 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXD8-associated genes across cancer lineages are RN7SL140P, RNA5SP235, and SNORD11B. Each is linked with HOXD8 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXD8-to-partner and partner-to-HOXD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL140P grouped by HOXD8-low versus HOXD8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD8→partner) and Y-score (partner→HOXD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL140P →	+0.088	+3.466	.008	.003	3	2
COAD	RNA5SP235 →	+0.653	+5.122	<.001	.004	3	2
UCEC	SNORD11B →	+0.499	+2.061	.001	.004	3	1
UCEC	NFYC-AS1 →	+0.464	+3.222	.002	.009	3	1
UCEC	KMT2B →	+0.512	+2.818	.001	.001	3	1
UCEC	DGCR11 →	+0.475	+3.593	.005	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,136 associations by consensus.

RN7SL140P by HOXD8 expression — UCEC

Explore this box plot interactively →