HOXD8

Across TCGA patient cohorts, HOXD8 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXD8-associated genes across cancer lineages are mTOR_pS2448, 14-3-3_beta, and Heregulin. Each is linked with HOXD8 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXD8-to-partner and partner-to-HOXD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by HOXD8-low versus HOXD8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD8→partner) and Y-score (partner→HOXD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.166	-2.459	.021	.020	3	2
UCEC	14-3-3_beta →	-0.115	-2.973	.018	.035	3	1
UCEC	Heregulin →	-0.164	-3.169	.005	.019	3	1
UCEC	Myosin-IIa →	+0.191	+2.177	.048	.035	3	1
UCEC	PKC-delta_pS664 →	-0.121	-3.169	.037	.018	3	1
UCEC	Smad3 →	+0.153	+3.321	.035	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

mTOR_pS2448 by HOXD8 expression — UCEC

Explore this box plot interactively →