HOXD8

Across TCGA cell cohorts, HOXD8 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible HOXD8-associated genes across cancer lineages are PRM3, USP17L3, and MBD3L2. Each is linked with HOXD8 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXD8-to-partner and partner-to-HOXD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRM3 grouped by HOXD8-low versus HOXD8-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD8→partner) and Y-score (partner→HOXD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PRM3 →	+0.138	+4.990	<.001	.001	3	1
OVARY	USP17L3 →	+0.006	+4.228	<.001	.006	3	1
OVARY	MBD3L2 →	+0.688	+4.029	<.001	.009	3	1
LUNG_NSCLC_LUAD	TAAR8 →	+0.022	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR1A2 →	+0.023	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR52E2 →	+0.341	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

PRM3 by HOXD8 expression — OVARY

Explore this box plot interactively →