HOXD13

Across TCGA patient cohorts, HOXD13 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,879 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible HOXD13-associated proteins across cancer lineages are TOP2A_S1377, NASP, and NT5DC2. Each is linked with HOXD13 in more than 4 cancer types. Because this analysis shows association rather than direction, both HOXD13-to-partner and partner-to-HOXD13 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HOXD13 versus TOP2A_S1377 in GBM, with a Pearson correlation of 0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD13→partner) and Y-score (partner→HOXD13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TOP2A_S1377 →	+0.968	+1.168	<.001	<.001	3	5
GBM	NASP →	+0.511	+1.152	.001	<.001	3	4
CCRCC	NT5DC2 →	+0.425	+0.333	<.001	<.001	3	4
UCEC	TOP2A →	+0.673	+0.389	.001	.009	3	4
HNSC	TOP2A_S1247 →	+0.896	+1.215	<.001	<.001	3	4
UCEC	TPX2 →	+0.598	+0.467	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,879 associations by consensus.

HOXD13 vs TOP2A_S1377 — GBM

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