HOXD12

Across TCGA patient cohorts, HOXD12 RNA expression is significantly associated with the protein abundance of many other proteins, with 8,305 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HOXD12-associated proteins across cancer lineages are TOPBP1, ZNF638_S128, and MSH2. Each is linked with HOXD12 in more than 4 cancer types. Because this analysis shows association rather than direction, both HOXD12-to-partner and partner-to-HOXD12 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HOXD12 versus TOPBP1 in LSCC, with a Pearson correlation of 0.42.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD12→partner) and Y-score (partner→HOXD12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TOPBP1 →	+0.406	+0.427	<.001	<.001	3	5
HNSC	ZNF638_S128 →	+0.341	+0.289	.002	.009	3	4
LSCC	MSH2 →	+0.460	+0.388	.002	<.001	3	4
LSCC	MSH6 →	+0.533	+0.372	.001	<.001	3	4
GBM	C1orf35 →	+0.352	+0.490	.008	.002	3	4
GBM	MCM2 →	+0.566	+0.488	.005	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,305 associations by consensus.

HOXD12 vs TOPBP1 — LSCC

Explore this scatter interactively →