HOXD10

Across TCGA patient cohorts, HOXD10 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXD10-associated genes across cancer lineages are EGFR_pY1068, PDCD4, and TFRC. Each is linked with HOXD10 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXD10-to-partner and partner-to-HOXD10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by HOXD10-low versus HOXD10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD10→partner) and Y-score (partner→HOXD10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.194	-1.765	.040	.014	3	2
UCEC	PDCD4 →	-0.474	-2.115	.007	.016	3	2
UCEC	TFRC →	+0.680	+1.765	<.001	.014	3	2
UCEC	Caspase-7-cleavedD198 →	+0.571	+1.874	.010	.049	3	2
UCEC	c-Jun_pS73 →	-0.119	-3.156	.046	.018	3	2
UCEC	14-3-3_beta →	-0.089	-2.432	.017	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

EGFR_pY1068 by HOXD10 expression — UCEC

Explore this box plot interactively →