HOXD10

Across TCGA pan-cancer cohorts, HOXD10 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of HOXD10’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HOXD10 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HOXD10 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

HNSC, KIRC, and KICH are the cancer types where HOXD10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HOXD10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+2.588	<.001	12	view →
KIRC	Female	II,III,IV	−1.848	<.001	12	view →
KICH	Male	All	−3.271	<.001	10	view →
KIRP	Female	All	−3.151	<.001	9	view →
COAD	Male	II,III,IV	−1.357	<.001	8	view →
LIHC	Male	All	+0.569	<.001	8	view →
LUSC	Male	All	+2.359	<.001	6	view →
BRCA	Female	II,III,IV	−0.714	<.001	6	view →
PAAD	All	All	+0.410	.019	4	view →
ESCA	Male	All	+0.490	.016	3	view →
READ	Female	All	−2.080	.001	2	view →
UCEC	All	All	−1.168	.043	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

HOXD10–HNSC

Open the HNSC breakdown →