HOXD1

Across TCGA patient cohorts, HOXD1 mutation is significantly associated with the RNA expression of many other genes, with 786 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXD1-associated genes across cancer lineages are MIR6803, LINC01943, and PAGR1. Each is linked with HOXD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXD1-to-partner and partner-to-HOXD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6803 grouped by HOXD1-low versus HOXD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD1→partner) and Y-score (partner→HOXD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6803 →	+0.212	+5.019	<.001	.001	3	2
UCEC	LINC01943 →	+0.577	+3.491	.001	.002	3	1
UCEC	PAGR1 →	+0.723	+3.595	<.001	.001	3	1
UCEC	IGKV1OR2-118 →	+0.223	+2.273	.003	.006	3	1
UCEC	ZNHIT3 →	+0.513	+3.606	.004	.001	3	1
UCEC	MIR6859-2 →	+0.450	+2.427	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 786 associations by consensus.

MIR6803 by HOXD1 expression — UCEC

Explore this box plot interactively →