HOXD-AS2

Across TCGA pan-cancer cohorts, HOXD-AS2 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated HOXD-AS2 data layer.

The strongest signal is observed in brain lower grade glioma (LGG), where higher HOXD-AS2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HOXD-AS2 expression acts as an unfavorable survival marker, although some lineages such as CHOL and OV show a favorable association.

LGG, CESC, and CHOL are the cancer types where HOXD-AS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.656	0.824	<.001	54	view →
CESC	DFS	Median	II,III,IV	0.594	0.803	.006	48	view →
CHOL	DFS	Tertile	II,III,IV	0.617	0.163	.004	44	view →
STAD	OS	Median	All	0.509	0.647	.003	36	view →
LIHC	OS	Median	All	0.700	0.857	.001	35	view →
UVM	OS	Median	III,IV	0.252	0.836	.005	30	view →
OV	OS	Median	II,III,IV	0.880	0.805	.009	26	view →
ESCA	DFS	Median	All	0.930	0.450	.003	24	view →
SKCM	OS	Quartile	III,IV	0.704	0.880	.005	22	view →
COAD	DFS	Median	II,III,IV	0.706	0.830	.006	16	view →
PRAD	DFS	Quartile	All	0.646	0.838	.001	16	view →
LUAD	DFS	Quartile	All	0.574	0.712	.010	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

HOXD-AS2–LGG (DFS)

Open the LGG breakdown →