HOXD-AS2

Across TCGA pan-cancer cohorts, HOXD-AS2 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of HOXD-AS2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HOXD-AS2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HOXD-AS2 is over-expressed in tumor, although a few such as UCEC and KICH show the opposite, repressed pattern.

HNSC, KIRC, and LIHC are the cancer types where HOXD-AS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HOXD-AS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	+0.947	<.001	11	view →
KIRC	All	III,IV	+0.451	<.001	9	view →
LIHC	Male	All	+0.440	<.001	8	view →
LUSC	Female	All	+0.865	<.001	7	view →
UCEC	All	All	−1.782	<.001	6	view →
KICH	Male	All	−1.125	<.001	6	view →
BRCA	Female	II,III,IV	−0.892	<.001	6	view →
ESCA	Male	All	+0.433	.009	3	view →
READ	All	All	−0.903	.002	2	view →
COAD	Male	II,III,IV	−0.512	.021	2	view →
LUAD	All	All	+0.338	.001	2	view →
THCA	All	All	+0.185	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

HOXD-AS2–HNSC

Open the HNSC breakdown →