HOXC9

Across TCGA patient cohorts, HOXC9 protein abundance is significantly associated with the go_rna of many other GO terms, with 122 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible HOXC9-associated GO terms across cancer lineages are Regulation of lamellipodium assembly, Negative regulation of epithelial to mesenchymal transition, and Negative regulation of cell-substrate junction organization. Each is linked with HOXC9 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXC9-to-partner and partner-to-HOXC9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of lamellipodium assembly grouped by HOXC9-low versus HOXC9-high in BRCA.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXC9→partner) and Y-score (partner→HOXC9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	Regulation of lamellipodium assembly →	+0.040	+0.496	.006	.003	3	1
BRCA	Negative regulation of epithelial to mesenchymal transition →	+0.057	+0.746	.001	.002	3	1
BRCA	Negative regulation of cell-substrate junction organization →	+0.067	+0.823	.001	<.001	3	1
BRCA	snRNA catabolic process →	+0.052	+0.774	.006	.002	3	1
BRCA	Urogenital system development →	+0.051	+0.705	.001	<.001	3	1
BRCA	Morphogenesis of a polarized epithelium →	+0.046	+0.789	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 122 associations by consensus.

Regulation of lamellipodium assembly by HOXC9 expression — BRCA

Explore this box plot interactively →