HOXC9

Across TCGA pan-cancer cohorts, HOXC9 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated HOXC9 data layer compared with 4 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher HOXC9 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HOXC9 expression acts as an unfavorable survival marker, although some lineages such as SCLC and BRCA show a favorable association.

ACC, UVM, and MESO are the cancer types where HOXC9 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.423	0.814	<.001	123	view →
UVM	OS	Median	II,III,IV	0.370	0.761	.001	59	view →
MESO	DFS	Tertile	II,III,IV	0.242	0.533	<.001	55	view →
LGG	OS	Median	All	0.695	0.911	<.001	54	view →
COAD	DFS	Tertile	All	0.377	0.597	.004	46	view →
LIHC	OS	Median	All	0.382	0.693	.001	45	view →
SCLC	DFS	Median	IV	0.651	0.148	.006	26	view →
ESCA	DFS	Quartile	All	0.330	0.583	.007	21	view →
SKCM	OS	Median	III,IV	0.760	0.857	.005	19	view →
HNSC	DFS	Quartile	II,III,IV	0.646	0.768	.010	18	view →
UCS	OS	Tertile	IV	0.308	0.761	.024	18	view →
LUAD	OS	Median	All	0.633	0.731	.005	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

HOXC9–ACC (OS)

Open the ACC breakdown →