HOXC9

Across TCGA patient cohorts, HOXC9 mutation is significantly associated with the RNA expression of many other genes, with 137 significant associations in total. COAD shows the largest number of these associations.

The most reproducible HOXC9-associated genes across cancer lineages are OR1E3, RN7SL74P, and RNU1-30P. Each is linked with HOXC9 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXC9-to-partner and partner-to-HOXC9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1E3 grouped by HOXC9-low versus HOXC9-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXC9→partner) and Y-score (partner→HOXC9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	OR1E3 →	+0.075	+5.182	<.001	.007	3	2
SKCM	RN7SL74P →	+0.174	+5.867	<.001	.003	3	2
HNSC	RNU1-30P →	+0.519	+6.763	<.001	<.001	3	2
UCEC	RNU1-68P →	+0.111	+4.069	<.001	.008	3	2
COAD	RNU6-1141P →	+1.123	+4.693	<.001	.007	3	2
COAD	RN7SL801P →	+0.826	+4.792	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 137 associations by consensus.

OR1E3 by HOXC9 expression — HNSC

Explore this box plot interactively →