HOXC8

Across TCGA patient cohorts, HOXC8 protein abundance is significantly associated with the RNA expression of many other genes, with 2,874 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible HOXC8-associated genes across cancer lineages are ZMAT3, LRRC3B, and RNA5SP245. Each is linked with HOXC8 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXC8-to-partner and partner-to-HOXC8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HOXC8 versus ZMAT3 in BRCA, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXC8→partner) and Y-score (partner→HOXC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZMAT3 →	+0.524	+0.876	.003	.002	3	1
BRCA	LRRC3B →	+0.084	+1.017	.001	.002	3	1
BRCA	RNA5SP245 →	+0.782	+1.150	.002	<.001	3	1
BRCA	CNTN4-AS2 →	+0.480	+1.119	.002	<.001	3	1
BRCA	LINC01743 →	-0.124	-0.863	.001	.005	3	1
BRCA	RN7SL861P →	+0.418	+0.959	.005	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,874 associations by consensus.

HOXC8 vs ZMAT3 — BRCA

Explore this scatter interactively →