Across TCGA patient cohorts, HOXC6 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXC6-associated genes across cancer lineages are eIF4E, FOXO3a_pS318_S321, and JNK2. Each is linked with HOXC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXC6-to-partner and partner-to-HOXC6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXC6→partner) and Y-score (partner→HOXC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.227	+3.700	.006	.001	3	1
UCEC	FOXO3a_pS318_S321 →	-0.098	-1.690	.044	.042	3	1
UCEC	JNK2 →	+0.232	+2.009	.002	.017	3	1
UCEC	Ku80 →	+0.337	+2.013	<.001	.005	3	1
UCEC	Notch1 →	+0.176	+1.750	.001	.049	3	1
UCEC	p62 Lck ligand →	+0.319	+1.884	.012	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Exploration

HOXC6 survival (RNA) · tumor vs normal (RNA) · all HOXC6 data types