Across TCGA pan-cancer cohorts, HOXC6 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of HOXC6’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HOXC6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HOXC6 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.
HNSC, BLCA, and LUAD are the cancer types where HOXC6 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HOXC6 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.