HOXC5

Across TCGA patient cohorts, HOXC5 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXC5-associated genes across cancer lineages are JNK2, p21, and Rad50. Each is linked with HOXC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXC5-to-partner and partner-to-HOXC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by HOXC5-low versus HOXC5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXC5→partner) and Y-score (partner→HOXC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.234	+2.834	.024	.034	3	1
UCEC	p21 →	+0.264	+2.820	.008	.035	3	1
UCEC	Rad50 →	-0.329	-3.000	.009	.036	3	1
UCEC	MEK1 →	+0.483	+3.000	.011	.036	2	1
UCEC	Notch1 →	+0.217	+3.009	.003	.019	2	1
UCEC	Shc_pY317 →	-0.230	-3.000	.003	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

JNK2 by HOXC5 expression — UCEC

Explore this box plot interactively →