Across TCGA patient cohorts, HOXC4 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,877 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible HOXC4-associated proteins across cancer lineages are POGZ, ARL3, and OBI1. Each is linked with HOXC4 in more than 4 cancer types. Because this analysis shows association rather than direction, both HOXC4-to-partner and partner-to-HOXC4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXC4→partner) and Y-score (partner→HOXC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	POGZ →	+0.239	+0.595	.004	.002	3	5
BRCA	ARL3 →	+0.402	+0.710	<.001	<.001	3	4
PDAC	OBI1 →	+0.405	+0.589	.001	<.001	3	4
GBM	SPINDOC_T49 →	+0.507	+0.908	<.001	<.001	3	4
COAD	COX5B →	-0.342	-0.660	.002	<.001	3	4
COAD	DBN1 →	+0.441	+0.659	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,877 associations by consensus.

Exploration

HOXC4 survival (RNA) · tumor vs normal (RNA) · all HOXC4 data types