HOXC13-AS

Across TCGA pan-cancer cohorts, HOXC13-AS RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated HOXC13-AS data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher HOXC13-AS RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HOXC13-AS expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCS show a favorable association.

ACC, LGG, and THCA are the cancer types where HOXC13-AS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.411	0.816	<.001	101	view →
LGG	OS	Tertile	All	0.668	0.850	<.001	48	view →
THCA	DFS	Tertile	II,III,IV	0.384	0.819	<.001	45	view →
KIRP	OS	Median	All	0.496	0.815	<.001	42	view →
MESO	OS	Quartile	II,III,IV	0.272	0.510	.009	38	view →
UCEC	OS	Tertile	All	0.881	0.944	.001	32	view →
HNSC	DFS	Tertile	IV	0.479	0.766	.004	21	view →
PRAD	DFS	Quartile	All	0.665	0.843	.002	18	view →
ESCA	DFS	Median	All	0.383	0.599	<.001	16	view →
LUSC	OS	Median	III,IV	0.409	0.652	.011	12	view →
GBM	OS	Quartile	All	0.304	0.495	.002	9	view →
SKCM	OS	Quartile	IV	0.730	0.269	.014	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

HOXC13-AS–ACC (OS)

Open the ACC breakdown →