HOXC13-AS

Across TCGA pan-cancer cohorts, HOXC13-AS RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of HOXC13-AS’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HOXC13-AS RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HOXC13-AS is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, LUSC, and LUAD are the cancer types where HOXC13-AS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HOXC13-AS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+2.076	<.001	12	view →
LUSC	Female	All	+1.997	<.001	9	view →
LUAD	Female	All	+0.492	<.001	8	view →
KIRC	Male	All	+0.073	.001	5	view →
KICH	All	All	−0.053	<.001	5	view →
STAD	All	All	+0.433	.004	4	view →
THCA	Female	All	+0.018	.033	1	view →
LIHC	All	All	+0.012	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

HOXC13-AS–HNSC

Open the HNSC breakdown →