HOXC12

Across TCGA cell cohorts, HOXC12 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HOXC12-associated genes across cancer lineages are SCGB1C1, C14orf180, and OOSP4A. Each is linked with HOXC12 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXC12-to-partner and partner-to-HOXC12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCGB1C1 grouped by HOXC12-low versus HOXC12-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXC12→partner) and Y-score (partner→HOXC12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SCGB1C1 →	+0.090	+4.714	.002	.002	3	1
LARGE_INTESTINE	C14orf180 →	+0.126	+4.155	<.001	.003	3	1
LARGE_INTESTINE	OOSP4A →	+0.115	+3.793	<.001	.007	3	1
LARGE_INTESTINE	NEXMIF →	+0.319	+4.196	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

SCGB1C1 by HOXC12 expression — BLOOD_Lymphoma

Explore this box plot interactively →