HOXC11

Across TCGA cell cohorts, HOXC11 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. CNS shows the largest number of these associations.

The most reproducible HOXC11-associated genes across cancer lineages are C14orf180, NAT8, and RPL10L. Each is linked with HOXC11 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXC11-to-partner and partner-to-HOXC11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C14orf180 grouped by HOXC11-low versus HOXC11-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXC11→partner) and Y-score (partner→HOXC11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C14orf180 →	+0.155	+3.477	<.001	.001	3	2
LARGE_INTESTINE	NAT8 →	+0.563	+3.443	.003	.009	3	1
LARGE_INTESTINE	RPL10L →	+0.208	+3.813	<.001	.003	3	1
LARGE_INTESTINE	OR10W1 →	+0.014	+3.562	<.001	.002	3	1
LARGE_INTESTINE	TAFA1 →	+0.234	+3.103	.002	.004	3	1
LARGE_INTESTINE	LRRC3C →	+0.296	+3.921	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

C14orf180 by HOXC11 expression — LARGE_INTESTINE

Explore this box plot interactively →