HOXB9

Across TCGA cell cohorts, HOXB9 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HOXB9-associated genes across cancer lineages are MS4A4A, MSGN1, and TAFA1. Each is linked with HOXB9 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXB9-to-partner and partner-to-HOXB9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A4A grouped by HOXB9-low versus HOXB9-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB9→partner) and Y-score (partner→HOXB9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MS4A4A →	+0.219	+3.678	<.001	.009	3	1
LARGE_INTESTINE	MSGN1 →	+0.100	+3.930	<.001	.003	3	1
LARGE_INTESTINE	TAFA1 →	+0.329	+4.688	<.001	<.001	3	1
LARGE_INTESTINE	C14orf180 →	+0.213	+4.155	<.001	.003	3	1
LARGE_INTESTINE	NEXMIF →	+0.319	+4.196	<.001	.002	3	1
LARGE_INTESTINE	TKTL2 →	+0.064	+4.187	<.001	.002	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MS4A4A by HOXB9 expression — LARGE_INTESTINE

Explore this box plot interactively →