HOXB8

Across TCGA patient cohorts, HOXB8 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,076 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible HOXB8-associated GO terms across cancer lineages are Anterior/posterior pattern specification, Embryonic skeletal system morphogenesis, and Glossopharyngeal nerve development. Each is linked with HOXB8 in more than 24 cancer types. Because this analysis shows association rather than direction, both HOXB8-to-partner and partner-to-HOXB8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Anterior/posterior pattern specification grouped by HOXB8-low versus HOXB8-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB8→partner) and Y-score (partner→HOXB8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Anterior/posterior pattern specification →	+0.044	+2.148	.004	<.001	3	25
SCLC	Embryonic skeletal system morphogenesis →	+0.099	+2.401	<.001	<.001	3	24
LAML	Glossopharyngeal nerve development →	+0.601	+1.340	<.001	<.001	3	23
SCLC	Embryonic skeletal system development →	+0.076	+3.054	<.001	<.001	3	23
UCS	Definitive hemopoiesis →	+0.084	+4.197	<.001	<.001	3	20
LAML	Cranial nerve morphogenesis →	+0.064	+0.952	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,076 associations by consensus.

Anterior/posterior pattern specification by HOXB8 expression — SCLC

Explore this box plot interactively →