HOXB8

Across TCGA pan-cancer cohorts, HOXB8 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated HOXB8 data layer compared with 3 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher HOXB8 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HOXB8 expression acts as an unfavorable survival marker, although some lineages such as THCA and CHOL show a favorable association.

KIRP, LUAD, and HNSC are the cancer types where HOXB8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	II,III,IV	0.396	0.939	<.001	64	view →
LUAD	OS	Tertile	All	0.595	0.727	.002	63	view →
HNSC	OS	Median	All	0.469	0.709	.001	54	view →
LGG	DFS	Median	All	0.665	0.791	<.001	49	view →
MESO	OS	Tertile	All	0.291	0.523	.004	48	view →
ACC	DFS	Tertile	All	0.289	0.740	<.001	39	view →
LIHC	OS	Tertile	All	0.598	0.820	<.001	31	view →
COAD	DFS	Quartile	All	0.674	0.866	.003	31	view →
READ	DFS	Tertile	II,III,IV	0.423	0.820	.001	29	view →
SKCM	OS	Quartile	All	0.829	0.924	.005	23	view →
BLCA	DFS	Quartile	IV	0.084	0.345	.015	21	view →
ESCA	OS	Median	All	0.659	1.000	.020	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

HOXB8–KIRP (DFS)

Open the KIRP breakdown →