HOXB8

Across TCGA patient cohorts, HOXB8 protein abundance is significantly associated with the RNA expression of many other genes, with 12,287 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HOXB8-associated genes across cancer lineages are SH3BP1, ICAM5, and MAST1. Each is linked with HOXB8 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXB8-to-partner and partner-to-HOXB8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HOXB8 versus SH3BP1 in UCEC, with a Pearson correlation of -0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB8→partner) and Y-score (partner→HOXB8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SH3BP1 →	-0.453	-0.589	.002	.002	3	1
UCEC	ICAM5 →	-0.707	-0.839	.001	.003	3	1
UCEC	MAST1 →	-0.569	-0.858	.002	.003	3	1
UCEC	NSUN5P2 →	+0.463	+0.515	<.001	.008	3	1
UCEC	HOXB6 →	+1.652	+0.815	<.001	<.001	3	1
UCEC	CRYAB →	-1.342	-0.865	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,287 associations by consensus.

HOXB8 vs SH3BP1 — UCEC

Explore this scatter interactively →