HOXB8

Across TCGA patient cohorts, HOXB8 protein abundance is significantly associated with the protein abundance of many other proteins, with 18,562 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HOXB8-associated proteins across cancer lineages are ANK2_S1755, ANK3_S959, and ARHGAP21_S253. Each is linked with HOXB8 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXB8-to-partner and partner-to-HOXB8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HOXB8 versus ANK2_S1755 in UCEC, with a Pearson correlation of -0.42.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB8→partner) and Y-score (partner→HOXB8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ANK2_S1755 →	-0.675	-0.702	<.001	.005	3	1
UCEC	ANK3_S959 →	+0.598	+0.812	<.001	<.001	3	1
UCEC	ARHGAP21_S253 →	-0.347	-1.080	.001	.003	3	1
UCEC	SAC3D1 →	-0.333	-0.805	<.001	.001	3	1
UCEC	SAP130_S465 →	+0.329	+0.991	<.001	.001	3	1
UCEC	SGIP1_T259 →	-0.559	-0.799	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,562 associations by consensus.

HOXB8 vs ANK2_S1755 — UCEC

Explore this scatter interactively →