HOXB8

Across TCGA patient cohorts, HOXB8 mutation is significantly associated with the RNA expression of many other genes, with 89 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXB8-associated genes across cancer lineages are RNU7-195P, RN7SL401P, and YWHAZP8. Each is linked with HOXB8 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXB8-to-partner and partner-to-HOXB8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-195P grouped by HOXB8-low versus HOXB8-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB8→partner) and Y-score (partner→HOXB8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU7-195P →	+0.517	+4.592	<.001	<.001	3	2
BLCA	RN7SL401P →	+0.059	+4.985	<.001	.002	3	2
LUAD	YWHAZP8 →	+0.064	+5.343	<.001	.006	3	2
LUAD	LINC02682 →	+0.988	+6.197	<.001	.001	3	2
UCEC	RN7SL197P →	+0.203	+3.599	.007	.007	3	1
UCEC	HMX3 →	+1.390	+3.859	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 89 associations by consensus.

RNU7-195P by HOXB8 expression — BLCA

Explore this box plot interactively →