HOXB8

Across TCGA cell cohorts, HOXB8 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HOXB8-associated genes across cancer lineages are ZSCAN1, DEFB108B, and TBL1Y. Each is linked with HOXB8 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXB8-to-partner and partner-to-HOXB8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZSCAN1 grouped by HOXB8-low versus HOXB8-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXB8→partner) and Y-score (partner→HOXB8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ZSCAN1 →	+0.039	+5.000	<.001	.006	3	1
PANCREAS	DEFB108B →	+0.032	+5.000	<.001	.006	3	1
PANCREAS	TBL1Y →	+0.006	+5.614	<.001	.002	3	1
BLOOD_Leukemia	KCNA10 →	+0.013	+5.539	<.001	.003	3	1
LARGE_INTESTINE	MSGN1 →	+0.126	+4.930	<.001	.001	3	1
LARGE_INTESTINE	TBC1D21 →	+0.015	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

ZSCAN1 by HOXB8 expression — PANCREAS

Explore this box plot interactively →